Prof. Dr. Nilgün Alptekin Demirkol

Prof. Dr. Nilgün Alptekin Demirkol

Biyokimya ve Klinik Biyokimya Uzmanı

  • Biyokimya ve Klinik Biyokimya Uzmanı

KİŞİSEL BİLGİLER

Adı Soyadı: Nilgün Alptekin Demirkol

Doğum Yeri: Bayburt

Uzmanlık Alanı:  Biyokimya ve Klinik Biyokimya 

  • Eğitim Bilgileri
  • İhtisas Eğitimi : İstanbul Üniversitesi, İstanbul Tıp Fakültesi- Biyokimya
  • Lisans Eğitimi : Yıldız Teknik Üniversitesi- Kimya Mühendisliği
  • Yabancı Dil: İngilizce
  • Mesleki Tecrübe ve Deneyim
  • 1984 yılında girmiş olduğu İstanbul Üniversitesi Biyokimya Anabilim Dalından “Sıçanlarda koledok kanalı ligasyonu ile oluşturulan karaciğer lipit peroksit ve glutatyon düzeyleri” konulu tezle ihtisasını tamamladıkdan sonra Amerika Birleşik Devletleri Tulane Üniversitesinde (New Orleans) 2 yıl Gastroenteroloji ve Peptid araştırma laboratuvarlarında araştırmacı olarak çalışmıstır.
  • 1994'te Biyokimya Doktorası ünvanı aldı
  • 1997'de Biyokimya anabilim dalı Doçentliği ünvanı almıştır.
  • 2005'te Biyokimya anabilim dalı Profesörlüğü ünvanını almıştır.
  • 2005'te 5 ay süreyle Avusturalya Royal Perth Hospital'de görevli olarak çalışmıştır.
  • 2004-2005 tarihleri arasında 2 yıl süre ile Fakülte Kurulu doçent temsilcisi olarak görev yapmıştır.

1.         Koçak-Toker N, Alptekin N, Manav G and Bilgin L K : Lipid peroxidation in diabetic senile cataract. Med Sci Res 16: 115-116,1988 
2.         Aykaç G, Özdemirler G, Alptekin N, Arıcan N, Öz B, Uysal M and Öz H : The hepatic lipid peroxidation, copper and fibrosis in cholestatic rats. Pharmacol Res 21 :701-706,1989.                                                                                             
3.         Yagcı R V, Alptekin N, Rossowski W J, Brown A, Coy D H and Ertan A : Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in rats. Scand J Gastroenterol 25: 853-858, 1990.                                      
4.         Alptekin N, Yağcı RV; Ertan A, Jiagn NY, RiceJC, Sbeiti M, Rossowski WJ and Coy DH.: Comparison of prolonged in vivo inhibitory activity of several potent bombesin (BN) antagonists on BN-Stimulated amylase secretion in the rat, Peptides, 12: 749-753, 1991.                                                                                               
5.         Yağcı R.V., Alptekin N, Zacharia S, Coy DH, Ertan A, Rossowski.: Galanin inhibits pancreatic amylase secretion in the pentobarbital-anesthetised rat. Regulatory Peptides 34: 275-282, 1991.                                                                                 
6.         Bozfakioğlu S, Alptekin N, Seçkin Ş, Ark E and Koçak-Toker N : Red cell lipid peroxidation and the antioxidant system in chronic renal failure patients treated with recombinant human erythropoietin. Nephron 61: 228-229,1992.                           
7.         Seçkin Ş, Alptekin N, Koçak-Toker N and Uysal M : Liver plasma membrane and erythrocyte Ca2+ ATPase activities in alloxan-treated rats. Med Sci Res 21: 539-540,1993.                                                                                                         
8.         Seçkin Ş, Alptekin N, Koçak-Toker N and Uysal M : Lipid peroxide and glutathione levels in the liver and its subcellular fractions of alloxan diabetic rats. Horm Metab Res 25: 444-445,1993.                                                                                          
9.         Koçak-Toker N,. Türkoğlu-Mutlu Ü., Alptekin N., Uysal M.: Effect of depletion of glutathione by buthionine Sulfoximine on lipid peroxidation in rats acutely treated with ethanol. Int J Biochem 25: 1765-1768, 1993.                                                                 
 
10.     Koçak-Toker N, Manav G, Alptekin N, Urgancıoğlu M.: Erythrocyte lipid peroxidation and antioxidant enzymes in Behçet’s disease. Med. Sci.Res 21: 789-790, 1993.     
      
11.     Seçkin Ş, Alptekin N, Koçak-Toker N, Uysal M, Aykaç-Toker G: Hepatic gamma-glutamyl cysteine synthetase and gamma-glutamyl transpeptidase activities in galactosamine-treated rats. Res Commun Molecul Pathol P  87: 237-240, 1995.      
12.     Alptekin N, -glutamyl transpeptidase activities in several tissues of rats following water-immersion stress. Pharmacol Res 34:167-169, 1996.                                                                                  gSeçkin Ş,  Doğru-Abbasoğlu S, Yelkenci F,  Koçak  N,  Toker G, Uysal M:  Lipid peroxides, glutathione, g-glutatmyl cysteine synthetase and 
13.     Mehmetçik G, Alptekin N, Toker G , Uysal M: Mitochondrial lipid peroxides and      antioxidant enzymes in the liver following phorone-induced glutathione depletion. Res Commun Molec Pathol P 96: 353-356, 1997.                                                    
14.     Seçkin Ş, Alptekin N, Doğru-Abbasoğlu S, Koçak-Toker N, Toker G, Uysal  M: The effect of chronic stress on hepatic and gastric lipid peroxidation in long-term depletion of glutathione rats. Pharmacol Res  36: 55-58, 1997.                              
15.     Alptekin N, Mehmetçik G, Uysal M, Aykaç-Toker G: Evidence for oxidative stress in the hepatic mitochondria of bile duct ligated rats. Pharmacol Res. 36:  243-248, 1997.                                                                                                                             
16.     Alptekin N,  Seçkin Ş, Doğru-Abbasoğlu s Koçak-Toker N, Çevikbaş U and Uysal M: Effect of vitamin C on glutathione and lipid peroxide levels in rats exposed to water immersion restraint stress. Med Sci Res 26: 590-597, 1998                          
                 
          17-Seçkin Ş, Alptekin N, Uysal M: The effects of starvation and cold restraint stress on lipid peroxidation,                      susceptıbılıty of VLDL+LDL to autooxidation and lipid levels in  the plazma of rats.Bioch Arch 15: 145150,1999                                                               
          18- Alptekin-Demirkol N, Seçkin S and Uysal M.: The effect of starvation and cold restraint stress on oxidative             damage in various tissues of rats. 15 th European Congress of Clinical  Chemistry and Laboratory Medicine,             P 195-198,2003.       
 
         19. Alptekin N, Çevikbaş U.: Taurine has protective effect against WIR stress- induced  in  several tissues                   damage of rats. Redox report (in press), 2004                   
 
 

 
·    The Association for Research in Vision and Ophthalmology (ARVD),
     Sarasota - Florida, April 30-May 5, 1989.
 
1-  Yagcı A, Alptekin N, Cefalu W T and Karcıoğlu Z A.: Lipit peroxide levels of serum, lens and retina in diabetic rats, Özet Kitabı, p: 30, 1989.
 
·      Southern AFCR Hematology, National Meeting, Washington DC, April 28-May 1,1989.
 
2-  Yeğinsü A O, Alptekin N, Yagcı R V, Arimura A and Ertan A.: Effects of stress on gastric and duodenal somatostatin-like immunoreactivity in rats, Clin Res, 37: A 15, 1989.
 
·      Digestive Disease Week and the 90TH Annual Meeting of the American Gastroenterological Association, Washington DC; May 13-19, 1989.
 
3-  Yagcı R V, Alptekin N, Rossowski W J, Brawn A, Coy D H and Ertan A.: Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in the rat, Gastroenterology, 96: A 554, 1989.
 
4-  Yeğinsü A O, Alptekin N, Yagcı  R V, Hammer R A, Arimura A and Ertan A.: Effect of stress on gastric and duodenal somatostatin-like immunoreactivity in rats, Gastroenterology, 96: A 559, 1989.
 
·      Hanse Selye Symposia on Neuroendocrinology and Stress, Neuroendocrinology of Gastrointestinal ulceration, Quebec, Canada, September 13-15, 1989.
 
5-  Yeğinsü A O, Alptekin N, Yagcı R V, Hammer R A, Arimura A and Ertan A.: Effect of stress on gastric and duodenal somatostatin-immunoreactivity in rats, Digest Dis Sci, 34:1322,1989.
 
6-  Yagcı R V, Alptekin N, Rossowski  W J, Brown A, Coy D H and Ertan A.: Inhibitory effect of galanin on basal and pentagastin-stimulated gastric acid secretion in the rat, Digest Dis Sci, 34: 1322, 1989.
 
·      Digestive Disease Week and the 91 ST Annual Meeting of the American Gastroenterological Association, San Antonio-Texas, May 12-18, 1990.
 
7-  Yagcı R V, Mahatma M, Nelson S, Hoda S A, Alptekin N, Brown D A, Agrawal N and Ertan A.: Prevention of gastric stress ulceration by misoprostol: Absence of relationship to tumor necrosis factor, Gastroenterology, 98: A 150, 1990.
 
8-  Alptekin N, Yagcı R V, Rossowski W J, Ertan A, Coy D H.: Prolonged in vivo inhibitory activity of potent bonbesin (BN) antagonists on BN- stimulated amylase release in the rat, Gastroenterology, 98: A 482,  1990.
 
9- Yagcı R V, Alptekin N, Zacharia S, Rossowski W J, Ertan A and Coy D H.: Galanin inhibits rat pancreatic exocrine secretion in vivo, Gastroenterology, 98: A 240, 1990.
 
• 15th IFCC-FESCC European Congress of Clinical Chemistry and Laboratory Medicine,Barselona, Spain, 1-5 June,  2003.
• 22nd National Congress of the Spanish of Clinical Biochemistry and Molecular Pathology. Barselona, Spain, 1-5 June, 2003
 
10- Alptekin-Demirkol N, Seçkin S, Uysal M.: The effect of starvation and cold restraint stress on oxidative damage in various tissues of the rats, Chemistry and Laboratory Medicine,P281,T-163, 2003.
 
• 29 th  Meeting of the Federation of the European Biochemical Societies, EJB The FEBS Journal, Warsow, Poland, 26 June- 1 July, 2004.
 
11- Alptekin-Demirkol N and Çevikbaş U.: Taurine has a protective effect against cold stress induced stomach and intestine damage in rats. EJB The FEBS Journal, V 271 suppl 1, July, P 246,2004.

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