Doç. Dr. Hakan Ulucan

Doç. Dr. Hakan Ulucan

Genetik Danışmanlığı

  • Genetik Danışmanlığı

KİŞİSEL BİLGİLER
 
Ad- Soyad: Hakan Ulucan
Doğum Yeri:
Uzmanlık Alanı: Genetik
 

  • Eğitim Bilgileri
  • Tıp Eğitimi: Ankara Üniversitesi Tıp Fakültesi (1984-1990)
  • Yabancı Dil: İngilizce (iyi derecede) ve Fransızca
  • Mesleki Tecrübe ve Deneyim
  • 01.12.1990-10.08.1992: Sağlık Ocağı Hekimi. Çanakkale İli Lapseki İlçesi Şevketiye Sağlık Ocağı - Pratisyen Hekim
  • 01.12.1994-15.09.1999: Doktora. Prof.J.M.Parry ve Dr.E.M.Parry gözetiminde İngiltere'deki Swansea Wales Üniversitesi Sitogenetik Labotatuvarı'nda "P53 geni modifiye edilmiş hücrelerde kromozom stabilitesi" konusunda doktora yapıldı.
  • 26.10.1999-21.03.2000: Aydın Adnan Menderes Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı-Uzman Araştırma Görevlisi
  • 06.08.2001-15.11.2001: Adnan Menderes Üniversitesi Tıp Fakültesi’nde Tıbbi Biyoloji Anabilimdalı - Uzman Araştırma Görevlisi
  • 11.10.2006-21.01.2010: Konuk Araştırmacı (Research Associate). Adnan Menderes Üniversitesi Tıp Fakültesi, Gülhane Askeri Tıp Akademisi ve National Institutes of Health, ABD arasında geliştirilen "Nadir görülen bazı genetik hastalıkların klinik ve moleküler analizi" isimli uluslararası işbirliği projesinin yürütücüsü olarak Amerika Birleşik Devletleri'nde İnsan gen haritalamasının yapıldığı ve yürütüldüğü NHGRI’da (İnsan Genom Araştırma Kurumu) çalışmaya başladım.
  • 18.09.2010- : Öğretim Üyesi (Doçent). İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Tıbbi Genetik Anabilim Dalı’nda Genetik Hastalıklar Tanı Merkezi’nin kurulmasında kurucu Mesul Müdür olarak görev aldım.
  • 19.06.2017- : Genetik Uzmanı. Genetik Hastalıklar, Genetik Toksikoloji, Riskli Gebelik ve Teratoloji konularında poliklinik hizmeti vermeye başladım

1.   The mechanisms of induced aneuploidy. European Union. Project Assistant. 1995-1999.
2.   A comparative study of molecular and conventional genetic methods for early and reliable diagnosis of malignant development in body fluids. Research Fund of Adnan Menderes University, Project Conductor. 2002-2005
3.   Acarlar: a model for safe adolescence. European Union, Project Consultant. 2006-2007
4. Clinical and molecular analysis of some rare genetic diseases. Supported by Human Genome Institute (NHGRI), NIH, Bethesda, USA, Project Conductor. 2006-2010
5. Effect of DNA repair gene polymorphisms on micronucleus index induced by benzopyrene in patients with age-related macular degeneration, Research Fund of Istanbul University, Project Assistant, 2010-2014
6. Analysis of patients with non-syndromic mental retardation using subtelomeric MLPA, Research Fund of Istanbul University, Project Assistant, 2011-2012
7. Designing and evaluating high resolution array CGH specific for skeletal dysplasias, Research Fund of Istanbul University, Project Assistant, 2011-2013
8. Mutation Analysis In Azoospermic Infertile Males Negative For Microdeletions on Chromosome Y. Research Fund of Istanbul University, Project Consultant, 2014-2015
9. Usage of pyrosequencing for routine methylation analysis of Beckwith-Wiedemann and Silver-Russell syndromes. Research Fund of Istanbul University, Project Consultant, 2014-2015
10. Analysis of associations between autism and some SNP variants in IL6 and IL1B genes. Research Fund of Istanbul University, Project Consultant, 2015-2016
11. Analysis of some SNPs of PAI1 gene on development of thrombophilia in patients with Klinefelter syndrome. Research Fund of Istanbul University, Project Consultant, 2015-2016
 

 

2000-Halen: Tıbbi Genetik Derneği üyeliği
2000-Halen: Biyokimya Derneği üyeliği
2003-2006: Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi yayın kurulu üyeliği ve hakemliği
2010- : İstanbul Tabip Odası Üyeliği
2013-2016: Tibbi Genetik Derneği Yönetim Kurulu Üyeliği
2015-2016: Medical Genetics Journal Kurucu Editörü

e genetic diseases. Supported by Human Genome Institute (NHGRI), NIH, Bethesda, USA, Project Conductor. 2006-2010
5. Effect of DNA repair gene polymorphisms on micronucleus index induced by benzopyrene in patients with age-related macular degeneration, Research Fund of Istanbul University, Project Assistant, 2010-2014
6. Analysis of patients with non-syndromic mental retardation using subtelomeric MLPA, Research Fund of Istanbul University, Project Assistant, 2011-2012
7. Designing and evaluating high resolution array CGH specific for skeletal dysplasias, Research Fund of Istanbul University, Project Assistant, 2011-2013
8. Mutation Analysis In Azoospermic Infertile Males Negative For Microdeletions on Chromosome Y. Research Fund of Istanbul University, Project Consultant, 2014-2015
9. Usage of pyrosequencing for routine methylation analysis of Beckwith-Wiedemann and Silver-Russell syndromes. Research Fund of Istanbul University, Project Consultant, 2014-2015
10. Analysis of associations between autism and some SNP variants in IL6 and IL1B genes. Research Fund of Istanbul University, Project Consultant, 2015-2016
11. Analysis of some SNPs of PAI1 gene on development of thrombophilia in patients with Klinefelter syndrome. Research Fund of Istanbul University, Project Consultant, 2015-2016
 

 

1. Parry EM, Ulucan H, Wyllie FS, Wynford-Thomas D, Parry JM. Segregational fidelity of chromosomes in human thyroid tumour cells. 1998 Chromosoma; 107: 491-497.
2. Dundaroz R, Ulucan H, Denli M, Karapinar K, Aydin HI, Baltaci V. Evaluation of DNA damage using the comet assay in children on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever. Pediatr Int. 2001 Jun;43(3):276-80.
3. Oktenli A, Ulucan H, Saglam M, Gul D. Camptodactyly, skeletal changes, ptosis and infertility in a male: a new syndrome? Clin Dysmorphol. 2001 Oct;10(4):295-7.
4. Dundaroz R, Aydin HI, Ulucan H, Baltaci V, Denli M, Gokcay E. Preliminary study on DNA damage in non breast-fed infants. Pediatr Int. 2002 Apr;44(2):127-30.
5. Gul D, Unay B, Ulucan H, Akin R. Unilateral split foot, torticollis, congenital heart defect and hydrocephaly: a new syndrome? Clin Dysmorphol. 2002 Apr;11(2):141-2.
6. Corso C, Ulucan H, Parry EM, Parry JM. Comparative analysis of two thyroid tumor cell lines by fluorescence in situ hybridization and comparative genomic hybridization. Cancer Genet Cytogenet. 2002 Sep;137(2):108-18.
7. Oktenli C, Ulucan H, Saglam M, Gul D. Facial dysmorphism, multiple pigmented nevi, osteoporosis, brachydactyly, and other skeletal changes in a male: a new syndrome? Clin Dysmorphol. 2003 Apr;12(2):149-51.
8. Dundaroz R, Ulucan H, Aydin HI, Gungor T, Baltaci V, Denli M, Sanisoglu Y.
Analysis of DNA damage using the comet assay in infants fed cow's milk. Biol Neonate. 2003;84(2):135-41.
9. Turkmen M, Ulucan H, Aydogdu SA, Bickici A, Inan G. Transient neonatal diabetes mellitus: a patient report. J Pediatr Endocrinol Metab. 2003 Sep;16(7):1057-9.
10. Oktenli C, Saglam M, Demirbas S, Thompson P, Upadhyaya M, Consoli C, Ulucan H, Koz C, Durukan AH, Bozkurt A, Koc B, Kocar IH, Gul D. A large deletion (1.5 Mb) encompassing the neurofibromatosis type 1 (NF1) gene in a patient with sporadic NF1 associated with dysmorphism, mental retardation, and unusual ocular and skeletal features. Clin Dysmorphol. 2003 Jul;12(3):199-201.
11. Koseoglu V, Kismet E, Soysal Y, Ulucan H, Dundaroz R, Imirzahoglu N, Gokcay E. Investigation of DNA damage in lymphocytes exposed to benzathine penicillin G. Pediatr Int. 2004 Aug;46(4):415-8.
12. Gul D, Ulucan H, Unay B, Akin R, Gokcay E. Acrocallosal syndrome: report of five Turkish patients. Clin Dysmorphol. 2004 Oct;13(4):241-6.
13. Ulucan H, Akin R, Kosem M, Gul D. De novo pericentric inversion of chromosome 5 in a girl with mental retardation and unilateral ear malformation. Am J Med Genet A. 2006 Feb 1;140(3):298-9. No abstract available.
14. Turgut M, Cullu E, Ulucan H. Incomplete Currarino triad as an embryological variant. Case report and review of the literature. J Neurosurg. 2006 Dec;105(6):504-7. Review.
15. Ulucan H, Gül D, Sapp JC, Cockerham J, Johnston JJ, Biesecker LG. Extending the spectrum of Ellis van Creveld syndrome: a large family with a mild mutation in the EVC gene. BMC Med Genet. 2008 Oct 23;9:92.
16. A rare case of split hand/foot malformation with sensorineural hearing loss and Mondini dysplasia. Gezdirici A, Yenigun A, Koparir E, Yosunkaya E, Ulucan H, Seven M, Yuksel A, Ozen M. Clin Dysmorphol. 2013 Jan;22(1):33-5.
17. Circumferential skin folds and multiple anomalies: confirmation of a distinct autosomal recessive Michelin tire baby syndrome. Ulucan H, Koparir E, Koparir A, Karaca E, Emre R, Gezdirici A, Yosunkaya E, Seven M, Ozen M, Yuksel A. Clin Dysmorphol. 2013 Apr;22(2):87-90.
18. A novel EFNB1 mutation in a patient with craniofrontonasal syndrome and right hallux duplication. Seven M, Gezdirici A, Ulucan H, Karatas OF, Yosunkaya E, Yuksel A, Ozen M. Gene. 2013 Sep 25;527(2):675-8.
19. Familial sick sinus syndrome. Sönmez O, Bacaksız A, Vatankulu MA, Ulucan H, Göktekin O. Anadolu Kardiyol Derg. 2013 Nov;13(7):727-8.
20. A novel frameshift mutation and infrequent clinical findings in two cases with Dyggve-Melchior-Clausen syndrome. Seven M, Koparir E, Gezdirici A, Aydin H, Skladny H, Fenercioğlu E, Güven G, Karataş ÖF, Koparir A, Özen M, Ulucan H. Clin Dysmorphol. 2014 Jan;23(1):1-7.
21. Poikiloderma with neutropenia: Genotype-ethnic origin correlation, expanding phenotype and literature review. Koparir A, Gezdirici A, Koparir E, Ulucan H, Yilmaz M, Erdemir A, Yuksel A, Ozen M. Am J Med Genet A. 2014 Oct;164(10):2535-40.
22. Global transcriptional disturbances underlie Cornelia de Lange syndrome and related phenotypes. Yuan B, Pehlivan D, Karaca E, Patel N, Charng WL, Gambin T, Gonzaga-Jauregui C, Sutton VR, Yesil G, Bozdogan ST, Tos T, Koparir A, Koparir E, Beck CR, Gu S, Aslan H, Yuregir OO, Al Rubeaan K, Alnaqeb D, Alshammari MJ, Bayram Y, Atik MM, Aydin H, Geckinli BB, Seven M, Ulucan H, Fenercioglu E, Ozen M, Jhangiani S, Muzny DM, Boerwinkle E, Tuysuz B, Alkuraya FS, Gibbs RA, Lupski JR. J Clin Invest. 2015 Feb;125(2):636-51.
23. Whole-exome sequencing revealed two novel mutations in Usher syndrome. Koparir A, Karatas OF, Atayoglu AT, Yuksel B, Sagiroglu MS, Seven M, Ulucan H, Yuksel A, Ozen M. Gene. 2015 Jun 1;563(2):215-8.
24. Genes that Affect Brain Structure and Function Identified by Rare Variant Analyses of Mendelian Neurologic Disease. E. Karaca, et al. Neuron. 2015 Nov 4;88(3):499-513.
25. Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.
Isrie M, Breuss M, Tian G, Hansen AH, Cristofoli F, Morandell J, Kupchinsky ZA, Sifrim A, Rodriguez-Rodriguez CM, Dapena EP, Doonanco K, Leonard N, Tinsa F, Moortgat S, Ulucan H, Koparir E, Karaca E, Katsanis N, Marton V, Vermeesch JR, Davis EE, Cowan NJ, Keays DA, Van Esch H. Am J Hum Genet. 2015 Dec 3;97(6):790-800.
26. DNA repair gene XPD Asp312Asn and XRCC4 G-1394T polymorphisms and the risk of autism spectrum disorder. Dasdemir S, Guven M, Pekkoc KC, Ulucan H, Dogangun B, Kirtas E, Kadak MT, Kucur M, Seven M. Cell Mol Biol (Noisy-le-grand). 2016 Mar 20;62(3):46-50

 

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